Types of CTCL

Cutaneous T-cell lymphoma (CTCL) is an umbrella term used to describe several related lymphomas. The most common forms—and the first to be identified—are Mycosis fungoides and Sézary syndrome. The term, however, now includes a number of additional diseases characterized by malignant T cell expansions.

Mycosis Fungoides (MF)

MF is the most common form of CTCL, accounting for 50% to 60% of all cases.^17,18

MF has an indolent course, with slow progression over many years or decades. It typically progresses from patches to plaques, and eventually to tumor development.¹⁷

While MF is generally limited to epidermal involvement, in some patients the disease slowly spreads to the lymph nodes and internal organs.¹⁷

Sézary syndrome (SS)

SS is an aggressive form of disease that affects approximately 5% of patients with CTCL.¹⁸

Additional CTCL classifications¹⁷

Other, less common forms of CTCL may be categorized according to their clinical form—indolent and aggressive. THERAKOS™ Photopheresis has not been evaluated in these less common forms.

Indolent form

• MF variants and subtypes
  • Folliculotropic MF
  • Pagetoid reticulosis
  • Granulomatous slack skin
• Primary cutaneous CD30+ lymphoproliferative disorders
  • Primary cutaneous anaplastic large cell lymphoma
  • Lymphomatoid papulosis
• Subcutaneous panniculitis-like T-cell lymphoma
• Primary cutaneous CD4+ small/medium pleomorphic T-cell lymphomas

Aggressive clinical form

• Primary cutaneous NK/T-cell lymphoma, nasal type
• Primary cutaneous aggressive epidermotropic CD8+ T-cell lymphoma (provisional)
• Primary cutaneous γ/δ T-cell lymphoma (provisional)
• Primary cutaneous CD4+ small/medium-sized pleomorphic T-cell lymphoma (provisional)