CTCL is a disease involving an imbalance in your immune system. THERAKOS™ Photopheresis therapy is thought to help restore your body's natural ability to maintain a balanced immune system.11
When your white blood cells are treated and then returned to your body, they may help your immune system to restore balance.
Here’s how it works. There are several types of T cells in the body. Think of these T cells as “damaging” cells and “regulating” cells.
In a healthy immune system, the regulating cells prevent the damaging cells from creating an imbalance in the body. But in someone with CTCL, there may be fewer regulating cells present to maintain this balance, so too many damaging cells will be produced by the immune system.
THERAKOS™ Photopheresis targets the regulating cells, resulting in a restoration of balance in the immune system—also called immunomodulation.
Although it is not yet completely understood how THERAKOS™ Photopheresis works, it appears that when treated cells are put back into your body, the regulating cells regain control over the damaging cells and help restore balance in your body.
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Methoxsalen Sterile Solution is indicated for extracorporeal administration with the THERAKOS™ UVAR XTS® or THERAKOS™ CELLEX® Photopheresis System in the palliative treatment of the skin manifestations of cutaneous T-cell lymphoma (CTCL) that is unresponsive to other forms of treatment.
Methoxsalen is not appropriate for patients who have had a reaction to psoralen compounds, patients who have had a light sensitive disease, or patients with an absence of one or both lenses of the eye.
THERAKOS™ Photopheresis is not appropriate for patients who cannot tolerate blood volume changes or patients with blood clotting disorders. See Important Safety Information for additional details.